Indian Journal of Public Health Research & Development

J. Bhuvaneswarri ¹, V. Ramya ¹, Preethe Padmanabhan ¹, Sajid T. Hussain ¹, U. Vidhya Rekha ¹

Affiliations
1 Department of Periodontics, Sree Balaji Dental College & Hospital, Velachery Main Road, Pallikaranai, Chennai, Tamilnadu, IN

Abstract

Periodontitis is a multifactorial diseasewhich is definedas Inflammation of the supporting tissuesof the teeth. It causes progressively destructive changeleads to loss of alveolar bone and periodontal ligament. An extensionof inflammation from gingiva into the alveolar bone and periodontal ligament.Periodontal disease is bacterial host interface disease. One such factor which is thought to be of host modulating is RANK/ RANKL system. This review is about the periodontal panorama about the system which might be therapeutic modulation of periodontal disease.

Keywords

Rankl, Rank, Bone Resorption, Bone Remodelling, Osteoprotegrin.

Full Text

     

Preethe Padmanabhan ¹, J. Bhuvaneswarri ¹, V. Ramya ¹

Affiliations
1 Department of Periodontics, Sree Balaji Dental College & Hospital, Velachery Main Road, Pallikaranai, Chennai, Tamilnadu, IN

Abstract

Stress is an association of physiological and psychological reactions of a person confronted to a change of situation he cannot face. The relationship between stress and any disease is explained by hormonal modifications and behavioural changes induced by the stress. Research has suggested that stress and depression are two factors that play a role inthe development and progression of periodontal disease. It is not clear, however, whether these factors lead to periodontal disease through physiological or behavioural changes, or by some combination of the two. The purpose of the present review article is to explore the associations between psychological factors, psycho immunologic variables, behaviour, and clinical measures of periodontal disease.

Keywords

Psychosocial Factors, Depression, Life Events, Glucocorticoids.

Full Text

     

V. Ramya ¹, J. Bhuvaneswarri ¹, Preethe Padmanabhan ¹

Affiliations
1 Department of Periodontics, Sree Balaji Dental College & Hospital, Velachery Main Road, Pallikaranai, Chennai, Tamilnadu, IN

Abstract

Compliment system is tradionally known as a cascade of anti microbial proteins in the blood. It is recognised as a key system for immune surveillance and homeostastis. It has a major link between the innate and the adaptative arms of the host immune response. They exist as pro enzymes and circulate as inactive forms. On activation, they become active, acquire enzymatic or esterase activity, react in particular sequence and cause damage to the neighbouring cells. This review discusses about the dysbiotic transformation of the periodontal pathogens that lead to destructive mechanism and loss of periodontal bone support.

Keywords

Complement Cascade, Haemostasis, Immunological Surveillance Toll Like Receptors, Gingipains.

Full Text

     

V. Ramya ¹, Sajid T. Hussain ¹, Preethe Padmanabhan ¹, T. Harshitha Reddy ²

Affiliations
1 Reader, Department of Periodontics, Sree Balaji Dental College and Hospital, BIHER, Chennai, IN
2 Post Graduate Student, Department of Periodontics, Sree Balaji Dental College and Hospital, BIHER, Chennai, IN

Abstract

Personalized medicine in Periodontics is considered as a new paradigm shift of future health care. It is considered to provide great help in identification of etiological factors, evaluating the host risk in clinical and genetic point of view and prediction of response of to treatment. It of great support in development of diagnostic, prognostic and therapeutic approach in a personalized way. As an overview we throw light on the advantages of personalized periodontal medicine over the usual conventional symptoms- oriented disease diagnosis and treatment.

Keywords

Pharmacogenomics, Microbiome, Periodontal Disease.

Full Text